RESUMO
1. The reasons which induced us to take up the study of rat leprosy are as folllows: a. The very close association between this disease and human leprosy. b. Human leprosy cannot be conveyed to lower animals, whereas almost 100 per cent of successes can be assured by inoculating rats with B. Leprae murium provided the appropriated technique is used. c. The course of the disease in the rat is a relatively rapid one. 2. As will be observed from the title, we discovered that structures resembling tumor growths occurred in the abdominal cavity following on the intra-abdominal inoculation of rat leprosy. Such growths, there is reason to believe, are granulomatous and are due to multiplication of the peritoneal endothelial cells and phagocysosis of bacilli together with multiplication of bacilli inside cells. We have also remarked on the fibrosis, caseation and liquefaction which ocur in the tumours. 3. We think taht a description of the mode of origin of these grwths may help to shed some light on the pathology of human leprosy and also, possibly, on the origin of other new growths more obscure in etiology.
Assuntos
Mycobacterium marinum/crescimento & desenvolvimentoRESUMO
So many remedies for leprosy are put forward nowadays that it may be useful to mention our experience of the effect of kala-azar in leprosy. For althought kala-azar is a debilitating disease, yet in the third stage of leprosy (B3 cases) in which the skin is loaded with lepra cells full of bacilli it produces a very marked and rapid improvement in the leprous condition.
Assuntos
Hanseníase/complicaçõesRESUMO
It has long been known that the iodides, especially the potassium salt, have a special action in leprosy. Most workers have regarded the apparent exacerbation produced by this drug as dangerous and a thing to be avoided. A few workers have considered it useful, especially in diagnosis because they found that nasal catarrh produced facilitated the search for lepra bacilli in the nasal secretion.
Assuntos
Hansenostáticos/efeitos adversos , Hansenostáticos/farmacocinética , Hansenostáticos/uso terapêuticoRESUMO
1) While the intravenous injection of sodium hydnocarpate may be admitted as the most effective means of administering hydnocarpus preparations, the blocking of veins has hitherto interfered with prolonged administration in this way.2) The sodium salts derived from a special fraction of H. wightiana and also the sodium salts of H. anthelmintica and alpina block the veins less than the salts from the whole H. wightiana oil.3) A new method of mixing the salts prepared from the whole oil of H. wightiana with blood before injection has received vein-blocking to a much more marked extent.4) Alternation of intravenous sodium hydnocarpate with subcutaneous infiltration of hydnocarpus oil with creosote is advised chiefly because of the haemolytic effect of the former preparations.
Assuntos
Chaulmoogra/administração & dosagem , Chaulmoogra/efeitos adversos , Chaulmoogra/uso terapêutico , Hansenostáticos/administração & dosagem , Hansenostáticos/análise , Hansenostáticos/uso terapêutico , Hanseníase/tratamento farmacológicoRESUMO
It has long been known that the iodides, especially the potassium salt, have a special action in leprosy. Most workers have regarded the apparent exacerbation produced by this drug as dangerous and a thing to be avoided. A few workers have considered it useful, especially in diagnosis because they found that nasal catarrh produced facilitated the search for lepra bacilli in the nasal secretion.